Plant Transcription Factor Database
Previous version: v3.0
Salvia miltiorrhiza
HD-ZIP Family
Species TF ID Description
SMil_00029472-RA_SalvHD-ZIP family protein
SMil_00019994-RA_SalvHD-ZIP family protein
SMil_00018130-RA_SalvHD-ZIP family protein
SMil_00012369-RA_SalvHD-ZIP family protein
SMil_00026667-RA_SalvHD-ZIP family protein
SMil_00002987-RA_SalvHD-ZIP family protein
SMil_00008151-RA_SalvHD-ZIP family protein
SMil_00018329-RA_SalvHD-ZIP family protein
SMil_00012115-RA_SalvHD-ZIP family protein
SMil_00024842-RA_SalvHD-ZIP family protein
SMil_00000968-RA_SalvHD-ZIP family protein
SMil_00016591-RA_SalvHD-ZIP family protein
SMil_00017359-RA_SalvHD-ZIP family protein
SMil_00029259-RA_SalvHD-ZIP family protein
SMil_00014051-RA_SalvHD-ZIP family protein
SMil_00018283-RA_SalvHD-ZIP family protein
SMil_00025063-RA_SalvHD-ZIP family protein
SMil_00012548-RA_SalvHD-ZIP family protein
SMil_00014289-RA_SalvHD-ZIP family protein
SMil_00019417-RA_SalvHD-ZIP family protein
SMil_00025062-RA_SalvHD-ZIP family protein
SMil_00002306-RA_SalvHD-ZIP family protein
SMil_00024745-RA_SalvHD-ZIP family protein
SMil_00008708-RA_SalvHD-ZIP family protein
SMil_00030384-RA_SalvHD-ZIP family protein
SMil_00011986-RA_SalvHD-ZIP family protein
SMil_00027288-RA_SalvHD-ZIP family protein
SMil_00000592-RA_SalvHD-ZIP family protein
SMil_00016837-RA_SalvHD-ZIP family protein
SMil_00030017-RA_SalvHD-ZIP family protein
SMil_00025868-RA_SalvHD-ZIP family protein
SMil_00010867-RA_SalvHD-ZIP family protein
SMil_00007035-RA_SalvHD-ZIP family protein
SMil_00003830-RA_SalvHD-ZIP family protein
SMil_00004381-RA_SalvHD-ZIP family protein
SMil_00020883-RA_SalvHD-ZIP family protein
SMil_00002684-RA_SalvHD-ZIP family protein
SMil_00017453-RA_SalvHD-ZIP family protein
SMil_00002781-RA_SalvHD-ZIP family protein
SMil_00027346-RA_SalvHD-ZIP family protein
SMil_00019750-RA_SalvHD-ZIP family protein
SMil_00020909-RA_SalvHD-ZIP family protein
SMil_00000335-RA_SalvHD-ZIP family protein
SMil_00001022-RA_SalvHD-ZIP family protein
SMil_00008641-RA_SalvHD-ZIP family protein
SMil_00005840-RA_SalvHD-ZIP family protein
SMil_00003140-RA_SalvHD-ZIP family protein
SMil_00023088-RA_SalvHD-ZIP family protein
SMil_00023736-RA_SalvHD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401